Free Fatty Acid Impairment of Nitric Oxide Production in Endothelial Cells Is Mediated
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چکیده
Arnold S. Baas, Pathmaja Paramsothy, Cecilia M. Giachelli, Marshall A. Corson and Elaine W. Francis Kim, Kelly A. Tysseling, Julie Rice, Matilda Pham, Lutfiyah Haji, Byron M. Gallis, β by IKK Free Fatty Acid Impairment of Nitric Oxide Production in Endothelial Cells Is Mediated Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2005 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/01.ATV.0000160549.60980.a8 2005; 2005;25:989-994; originally published online February 24, Arterioscler Thromb Vasc Biol. http://atvb.ahajournals.org/content/25/5/989 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Free Fatty Acid Impairment of Nitric Oxide Production in Endothelial Cells Is Mediated by IKK
Objective—Free fatty acids (FFA) are commonly elevated in diabetes and obesity and have been shown to impair nitric oxide (NO) production by endothelial cells. However, the signaling pathways responsible for FFA impairment of NO production in endothelial cells have not been characterized. Insulin receptor substrate-1 (IRS-1) regulation is critical for activation of endothelial nitric oxide synt...
متن کاملFree fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta.
OBJECTIVE Free fatty acids (FFA) are commonly elevated in diabetes and obesity and have been shown to impair nitric oxide (NO) production by endothelial cells. However, the signaling pathways responsible for FFA impairment of NO production in endothelial cells have not been characterized. Insulin receptor substrate-1 (IRS-1) regulation is critical for activation of endothelial nitric oxide synt...
متن کاملNitric oxide and the bioactivities
Nitric oxide (NO), previously known as Endothelium-Derived Relaxing Factor (EDRF) is involved in a wide range of physiological and pathophysiological mechanisms. It is synthesized endogenously by the enzymes Nitric Oxide Synthase (NOS) in specialized tissues from its precursor L-arginine, yielding L-citrulline as a byproduct. It is released by a family of isoenzymes, viz., the endothelial (eNOS...
متن کاملNitric oxide and the bioactivities
Nitric oxide (NO), previously known as Endothelium-Derived Relaxing Factor (EDRF) is involved in a wide range of physiological and pathophysiological mechanisms. It is synthesized endogenously by the enzymes Nitric Oxide Synthase (NOS) in specialized tissues from its precursor L-arginine, yielding L-citrulline as a byproduct. It is released by a family of isoenzymes, viz., the endothelial (eNOS...
متن کاملResveratrol analog piceatannol restores the palmitic acid-induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti-inflammatory and antioxidative heme oxygenase-1 in human endothelial cells
Growing evidence suggests that the elevation of free fatty acids, including palmitic acid (PA), are associated with inflammation and oxidative stress, which may be involved in endothelial dysfunction, characterized by the reduced bioavailability of nitric oxide (NO) synthesized from endothelial NO synthase (eNOS). Heme oxygenase-1 (HO-1) is important in the preservation of NO bioavailability. P...
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تاریخ انتشار 2005